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导师简介

韩小瑜

2018/03/29 15:34:50 次浏览 分类:导师简介


   

 

韩小瑜,女,博士、教授,硕士研究生导师。 2012年毕业于新加坡国立大学,获理学博士学位。2012年-2014年,在新加坡国立大学从事博士后研究工作。2014年3月回国加入浙江科技学院工作至今。主要研究方向为有机合成、药物合成、制药工艺研发及有机功能材料合成。其首次报道的手性二肽膦催化剂由于其高效的催化效率以及广泛的应用范围已被日本东京化成(TCI)试剂公司和上海大赛璐药物手性技术有限公司商业化,市场前景可观。已在包括J.Am.Chem.Soc(美国化学会志), Angew.Chem.Int.Ed.(德国应用化学)等国际顶级及权威期刊在内的刊物上发表SCI论文30余篇。主持了包括国家自然科学基金、浙江省自然科学基金、浙江省钱江人才计划、新加坡政府工业应用项目等项目,获得了包括浙江省中青年学科带头人、浙江科技学院青年英才、新加坡国立大学最佳论文奖、国家优秀自费留学生奖及爱思唯尔博士奖在内的诸多荣誉及奖项。现为Chem.Commun.Org.Biomol.Chem.Curr.Org.Chem.、Synlett等杂志特约审稿人。


主持基金项目

[1] 国家自然科学基金(主持):新型手性膦催化构建结构多样性五/六元碳环和杂环分子的合成研究(No.21402177)

[2] 浙江省自然科学基金(主持):基于二取代氨基醇的多功能手性叔膦催化剂的设计合成及其应用研究(No.LY17B02003)

[3] 浙江省钱江人才计划(主持):新型手性膦催化剂的开发及其在生物活性分子合成中的应用No. QJD1602024

[4]新加坡政府工业应用项目(主持):Development of asymmetric synthetic methods in aqueous media amenable for green and sustainable manufacturing (No. R-143-000-469-112);

发表论文

1. Chang Zhixin; Ye Can; Fu Junfeng, Chigumbu Paidamoyoa, Zeng Xiaofei, Jiang Chengjun, Wang Yongjiang; Han, Xiaoyu*; “Enantioselective Synthesis of Oxindole-derived a-Aryl-b-Amino Acid Derivatives and Lactames with Homophthalic Anhydrieds”, Adv. Syn. Cat. 2020,361,5516-5520. (IF=5.451)

2. Chen Fenfen; Chang Zhixin; Chigumbu Paidamoyoa; Wang Yongjiang* Han, Xiaoyu*; “Enantioselective Synthesis of Tertiary Trifluoromethyl Carbinol via Vinylogous Aldol Reaction of b-Methylcyclohexenone with Aryl Trifluoromethyl Ketones”, Synlett 2019, 30, 240. (IF=2.419)

3. Han, Xiaoyu*; Ye Can; Chen Fenfen; Wang Yongjiang; Zeng Xiaofei “A highly enantioselective Friedel–Crafts reaction of 3,5-dimethoxylphenol with nitroolefins mediated by a bifunctional quinine derived thiourea catalyst”, Org. Biomol. Chem. 2017, 15, 3401. (IF=3.562)

4. Han, Xiaoyu*; Chen Fenfen; Ye Can; Wang Yongjiang* “Enantioselective Conjugate Addition of Azlactones to Nitroolefins with a Thiourea-Based Bifunctional Organocatalyst”, Synlett 2017, 28, 989. (IF=2.419)

5. Han, Xiaoyu*; Chan Wai-Lun; Yao Weijun; Wang Yongjiang; Lu, Yixin* “Phosphine- mediated Highly Enantioselective Spirocyclization with Ketimines as Substrates”, Angew. Chem. Int. Ed. 2016, 55, 6492. (IF=11.261)

6. Han, Xiaoyu*; Ni, Huanzhen; Chan, Wai-Lun; Gai, Xikun; Wang, Yongjiang; Lu, Yixin* “Highly Enantioselective Synthesis of Dihydrocoumarin-fused Dihydropyrans via the Phosphine-catalyzed [4+2] Annulation of allenones with 3-Aroylcoumarins” Org. Biomol. Chem. 2016, 14, 5059. (IF=3.562)

7. Wang, Tianli; Han, Xiaoyu; Zhong, Fangrui; Yao, Weijun; Lu, Yixin* “Amino Acid-Derived Bifunctional Phosphines for Enantioselective Transformations”, Acc. Chem. Res. 2016, 49, 1369. (IF=22.003)

8. Han, Xiaoyu*; Gai, XikunWang, Yongjiang; Zeng, Xiaofei* “Highly Enatio- and Diaster- eoselective L-Proline Derived Acetyl-glucose Amide Catalyzed Aldol Reaction of Ketones to Aldehydes under Solvent-free Conditions” Synlett 2015, 26, 2858. (IF=2.419)

9. Han, Xiaoyu; Yao, Weijun; Wang, Tianli; Tan, Yong Ren; Yan Ziyu; Kwiatkowski, Jacek; Lu, Yixin* “Asymmetric Synthesis of Spiropyrazolones via Phosphine- catalyzed [4+1] Annulation”, Angew. Chem. Int. Ed. 2014, 53, 5643. (IF=11.261)

10. Han, Xiaoyu; Zhong, Fangrui; Wang, Youqing; Lu, Yixin* “Versatile Enantioselective [3+2] Cyclization between Imines and Allenoates Catalyzed by Dipeptide-Based Phosphines”, Angew. Chem. Int. Ed. 2012, 51, 767. (IF=11.261)

11. Han, Xiaoyu; Wang, Youqing; Zhong, Fangrui; Lu, Yixin* “Enantioselective [3+2] Cycloaddition of Allenes to Acrylates Catalyzed by Dipeptide-derived Novel Phosphines: Facile Creation of Functionalized Cyclopentenes Containing Quaternary Stereogenic Centers”, J. Am. Chem. Soc. 2011, 133, 1726. (IF=12.113)

12. Han, Xiaoyu; Wang, Youqing; Zhong, Fangrui; Lu, Yixin* “Enantioselective Morita- Baylis-Hillman Reaction Promoted by L-Threonine-Derived Phosphine -Thiourea Catalysts”, Org. Biomol. Chem. 2011, 9, 6734. (IF=3.562)

13. Han, Xiaoyu; Wang, Su-Xi; Zhong, Fangrui; Lu, Yixin* “Formation of Functionalized Cyclopentenes via Catalytic Asymmetric [3+2] Cycloaddition of Acrylamides with Allenes Promoted by Dipeptide-derived Phosphines”, Synthesis 2011, 1859. (IF=2.689)



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