吴志宏

吴志宏

Zhihong Wu, PhD

邮箱：zhihong.wu@zust.edu.cn

个人简介

吴志宏博士， 1987年和1994年在浙江农业大学分别获得学士和硕士学位；2005年在德国基尔大学获得细胞生物学博士学位；2006-2014年在德国基尔大学医学院皮肤病研究所任博士后研究、抗菌肽研究中心课题组长、资深研究员。2014年6月加入浙江科技学院工作，担任特聘教授。

研究方向

长期从事皮肤先天免疫方面的基础研究，并致力于研究成果的产业化。研究受德国自然科学基金重点项目、德国重大研发专项、欧共体重大研发专项和我国自然科学基金面上项目（2015-2018，2017-2020和2019-2022共3项）。研究成果在主流杂志NATURE、PNAS、JBC和JID等上发表，并于2019年入选南太湖创新创业精英计划领军人物团队。

代表性论文

1. Zhihong Wu, Ulf Meyer-Hoffert, Katrin Reithmayer, et al. (2009). Highly Complex Peptide Aggregates of the S100 Fused-Type Protein Hornerin Are Present in Human Skin. J Invest Dermatol 129: 1446-1458.

2. Ulf Meyer-Hoffert*, ZhihongWu*, Jens-Michael Schröder (2009) Identification of Lympho-Epithelial Kazal-Type Inhibitor 2 in Human Skin as a Kallikrein-Related Peptidase 5-Specific Protease Inhibitor. PLoS ONE 4(2): e4372. (*Co-first Author).

3. Zhihong Wu, Britta Hansmann, Ulf Meyer-Hoffert, Regine Gläser and Jens-Michael Schröder (2009)  Molecular Identification and Expression analysis of Filaggrin-2, a Member of the S100 Fused-Type Protein Family. PLoS ONE 4(4): e5227.

4. Meyer-Hoffert U*, Wu Z*, Kantyka T, Fischer J, Latendorf T, Hansmann B, Bartels J, He Y, Gläser R, Schröder JM. (2010) Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases. J Biol Chem 285(42): 32174-81.  (*Co-first author). This article was picked and evaluated by Faculty of 1000 members and has received a F1000 Score of 6.0 (>=6 = Must read).

5. 5.Björn O. Schröder, Zhihong Wu, Sabine Nuding, Sandra Groscurth, Moritz Marcinowski, Julia Beisner, Johannes Buchner, Martin Schaller, Eduard F. Stange and Jan Wehkamp. (2011) Reduction of disulfide bonds unmasks potent antimicrobial activity of human ß-defensin 1. Nature 469: 419-423. Featured by Nature, “ Immunology: Peptide gets in shape for self-defence” (News and Views by Robert I. Lehrer). This article was picked and evaluated by Faculty of 1000 members and has received a F1000 Score of 10.0 (>=8 = important).

6. Kantyka T, Fischer J, Wu Z, Wim Declercq, Karina Reiss, Schröder JM, Meyer-Hoffert U. (2011) Inhibition of Kallikrein-related Peptidases by the Serine Protease Inhibitorof Kazal-type 6. Peptides 32(6):1187-92

7. Zhihong Wu, Ties Latendorf, Ulf Meyer-Hoffert and Jens-Michael Schröder. (2011) Identification of Trichohyalin-Like 1, an S100 Fused-Type Protein Selectively Expressed in Hair Follicles. J Invest Dermatol  131(8): 1761-1763

8. Reiss, Karina; Meyer-Hoffert, Ulf; Fischer, Jan; Maria Sperrhacke, Maria; Wu, Zhihong; Dimitrieva, Olga; Krenek, Pavel; Buryova, Halka; Suchanova, Sarka; Brauer, Rena; Sedlacek, Radislav. (2011) Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2. Exp Dermatol 20(11): 905-910

9. Hansmann, Britta; Ahrens, Kerstin; Wu, Zhihong; Proksch, Ehrhardt; Meyer-Hoffert, Ulf; Schröder, Jens-Michael. (2012) Murine filaggrin-2 is involved in epithelial barrier function and down-regulated in metabolically induced skin barrier dysfunction. Exp Dermatol 21(4):271-76

10. Jan Fischer, Yulia Koblyakova, Ties Latendorf, Zhihong Wu, Ulf Meyer-Hoffert. (2013) Cross-linking of SPINK6 by transglutamination protects from eprdermal proteases. J Invest Dermatol 133:1170–1177

11. Zhihong Wu, Yuanyuan Wu, Jan Fischer, Joachim Bartels, Jens-Michael Schroeder,Ulf Meyer-Hoffert.(2019) Skin-Derived SPINK9 Kills Escherichia coli.J Invest Dermatol 139:1135–1142